4-21 Benefits of Xylitol 

Allergies, Otitis Media and Asthma Decreased with Xylitol
   "There is growing interest on the part of both patients and providers in the use of complementary and alternative medicine therapies to treat allergy, otitis media, and asthma. 
   Studies suggest possible efficacy for some vitamin and mineral supplements for allergic diseases; results are less clear in asthmatic patients. The use of polyunsaturated fatty acids appears particularly promising for treatment and even prevention of allergy and asthma conditions. Studies also suggest that probiotic preparations have a role in the treatment of allergic conditions.
   Xylitol gum, syrup, and lozenges have shown efficacy in treatment of acute otitis media, as have some naturopathic herbal remedies. 
   Preliminary results with studies of yoga and various relaxation therapies for treatment of asthmatics suggest that these therapies may have a role.. (Blazek-O'Neill, 2005).
   "Xylitol is a polyol sugar alcohol and is referred to as birch sugar, because it can be produced from birch. Natural sources of xylitol include plums, strawberries, raspberries and rowan berries. Xylitol inhibits the growth of Streptococcus pneumoniae and it inhibits the attachment of both pneumococci and Haemophilus influenzae on the nasopharyngeal cells.
    In two clinical trials xylitol was found efficient to prevent the development of acute otitis media with a daily dose of 8.4-10 g of xylitol given in five divided doses.
   The efficacy in these 2-3 months follow-up trials was approximately 40% when chewing gum was used and approximately 30% with xylitol syrup. The need to use antimicrobials reduced markedly when using xylitol. In a high-risk group of children with tympanostomy tubes xylitol was ineffective in preventing otitis. Xylitol appears to be an attractive alternative to prevent acute otitis media." (Uhari,2000).

Xylitol Decreases Streptococcus and C. Difficile
   Growing evidence from clinical studies suggests that mothers using xylitol gums or lozenges have decreased levels of Streptococcus mutans (SM) and do not transmit these cariogenic bacteria as readily to their children.
   To assess the ability of SM to adhere, microtiter plate wells coated with primary S. sanguinis biofilms grown in sucrose were inoculated with treated SM, and adhesion was determined. Cells exposed to CHX-XYL combinations exhibited significant but transient inhibition of growth.
    We concluded that significant inhibition of SM growth and subsequent inability to grow as biofilms in the presence of sucrose occurs after a staggered exposure regimen to CHX initially and then to XYL. (Modesto,2006).
   "Bacteraemia and subsequent sepsis is one possible complication of Clostridium difficile infection. The influence of pro- and pre-biotics (lactobacilli and xylitol) were also studied in the hamster model.
   In cases of mild C. difficile infection, the extent of disturbance of intestinal microflora appeared to be a more important promoting factor in translocation than inflammatory activity in the mucosa. Translocation was frequent in fatal enterocolitis, with facultative species predominating in the intestinal mucosa and also C. difficile in some cases. The combination of lactobacilli and xylitol had some protective effect against C. difficile infection." (Naaber,1998).

Xylitol Decrease Biofilm and Improves Dermatitis
   Staphylococcus aureus (SA) discharges various toxins and enzymes that injure the skin, and forms a biofilm from fibrin fiber and glycocalyx; the biofilm is important for adhesion of SA to the skin and for resistance to anti-microbial agents. Even highly effective moisturizers do not work perfectly on atopic dry skin. Staphylococcus epidermidis (SE) is a major constituent of skin microflora on healthy human skin, and provides protection against the growth of pathogenic bacteria. 
   We found that xylitol inhibited the formation of glycocalyx, and farnesol dissolved fibrin fibers. Farnesol suppressed the growth of only SA, and did not affect that of SE. Xylitol and farnesol synergistically inhibited biofilm formation by SA.
   Xylitol and farnesol have potential for controlling the skin-microfloral balance because of their selective effects and inhibition of biofilm formation. They might provide a useful and safe method to care for skin colonized by SA, without using antibiotics." (Katsuyama,2005). 
   Another study notes, "it is recognized that colonization by Staphylococcus aureus (SA) on the skin is one of the factors that can worsen atopic dermatitis (AD). Antibiotics and germicides are not the best choice to remove bacteria from the skin of AD patients, because of problems of irritation to the skin and bacterial resistance. We therefore turned our attention to the biofilm of SA with the aim of removing only SA from the skin surface of AD patients. We found that xylitol (X) and farnesol (F) synergistically inhibited biofilm formation by SA and dissolved biofilm formed in vivo. (Katsuyama,2005).
   An earlier study notes, "coagulation by S. aureus cells was inhibited in plasma containing farnesol at a concentration of 1/12 of the MIC (100 microg/ml) after incubation for 24 h. 
   Farnesol is a promising adjuvant agent against S. aureus skin infections treated with beta-lactam antibiotics. Further, 5% xylitol inhibited glycocalyx production by S. aureus cells and consequently had a suppressive effect on the colonization of S. aureus on the horny cells of AD lesions."  (Akiyama,2002).

Xylitol’s Effect on Calcium Absorption
   "We compared the effect of a variety of sugar alcohols on calcium absorption from the rat small and large intestine in vitro. 
   The addition of 0.1-200 mM erythritol, xylitol, sorbitol, maltitol, palatinit, or lactitol to the mucosal medium affected net Ca absorption in the intestinal preparations. Differences in Ca transport were observed between portions of the intestine, but not between sugar alcohols tested. We concluded that sugar alcohols directly affect the epithelial tissue and promote Ca absorption from the small and large intestine in vitro." (Mineo,2002).

Food Additives and The Gut
   "Food additives, drugs, and other chemicals are known to influence the lower gastrointestinal tract under some defined conditions, resulting in morphological alterations in the mucosa and other tissues, deranged absorption and excretion of nutrients, and, in some cases, injury to other organs and tissues as a secondary phenomenon. Generally, in rats, hamsters, and dogs, there is increased absorption and urinary excretion of calcium, soft stools or diarrhea, and cecal enlargement. In the rat, hamster, and dog, renal lesions accompany the hypercalcemia and elevated excretion of calcium. These signs, symptoms, and lesions are typical of exposure to sugar alcohols (sorbitol, mannitol, xylitol, lactitol), lactose and caramel, some of the chemically modified food starches, and synthetic polydextrose. 
   Soft stools and diarrhea, as well as cecal enlargement and variable hyperplasia of the colon mucosa, occur frequently when substances are absorbed incompletely in the small intestine and subjected to microbial metabolism in the cecum and colon.
   The remarkable cecal enlargement, mucosal hyperplasia and, when present, colonic mucosal hyperplasia are reversible, even when long-standing. Renal lesions are reversible only if exposure is of short duration, before significant mineralization and scarring has occurred" (Newberne,1988).

Xylitol and Vitamin Sparing
   "The changes induced by dietary xylitol in the gastrointestinal tract of the rat were investigated in relation to the phenomenon of vitamin-sparing. Within 18 days of consuming a synthetic diet, deficient in thiamin, riboflavin and pyridoxine, rats ceased to grow and began to lose weight rapidly. If xylitol was then included in the diet (10% w/w), the effect of the vitamin-deficient diet on growth was reversed. 
   Moreover, within 3 days of the rats ingesting xylitol, the metabolism of this sugar polyol by the caecal microflora was increased 17-fold and the caecal concentrations of thiamin and thiamin pyrophosphate were increased 5-fold. Increases were also observed in the caecal size, the weight of the caecal contents, and the weight of the caecal wall. In contrast to the rapid changes observed within the caecum, liver thiamin pyrophosphate levels did not rise until 6-12 days after the feeding of xylitol, at which time the rats had begun to gain weight. 
   The cecal contents were shown to contain facultative bacteria which have the ability to metabolise and grow on xylitol and which can, at the same time, synthesise thiamin. Species of the genera Klebsiella, Serratia and Micrococcus which have this ability were isolated from the caecal contents of rats. It is assumed that coprophagy is the means by which the thiamin and other vitamins synthesised by enteral bacteria become available to the host, although some absorption from the caecum cannot be excluded." (Rofe,1982).

Early Studies
   Early references to Xylitol include: Hutcheson, & Reynolds, et al. (1956). "The reduction of L-xylulose to xylitol by guinea pig liver mitochondria." J Biol Chem 221(2): 697-709.
   "Guinea pig liver mitochondria catalyze the reduction of L-xylulose to xylitol, which was identified as its crystalline pentaacetyl derivative. 
   The enzyme system is located in the insoluble portion of the mitochondria and appears to involve pyridine nucleotides.
   The high order of specificity of the system was evident from its lack of activity toward all ketoses and polyols tested other than L-xylulose and xylitol. The substrate specificity differentiates the mitochondrial enzyme from other enzymes which are known to catalyze the interconversion of ketoses and polyols."
   In 1961, Kieckebuch et al wrote: "[The usefulness of xylitol as a nutritional carbohydrate and its tolerance.]." in Klin Wochenschr..
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7-4 NeuroAnatomy Study List for Manual Therapists, The Burnham Review

7-5 Manual Therapy and the Peace Process, The Burnham Review

8-10: An Osteopathic Approach to Viral Infections, Influenza & Pathogenic Processes, The Burnham Review

8-05: Osseous Bridging, The Burnham Review

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7-15: Fibromyalgia and Chronic Pain, The Burnham Review Aug 2007

7-09: Parkinson's Disease and Integrative Manual Therapy, The Burnham Review May 2007

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Virtual Library

    Experience your Virtual Library Card Today. The Virtual Library Card and a monthly newsletter on topics of interest and holdings in the library is available for $29.95 per year. Access to all five libraries is $100 per year. [Go To Shopping Cart]

    Your Virtual Library Card includes a monthly e-newsletter, access to hundreds of web pages and reference material beyond what the general public can view, and 2 special requests for information on a specific topic (4-10 page report including abstracts and resources available). These are written and researched by Kimberly Burnham, Virtual Librarian and real person. She uses her extensive research capabilities and education developed during her PhD in Integrative Medicine, 10 years as Director of Knowledge Management at the Center for Integrative Manual Therapy and Diagnostics as well as a practitioner, teacher and researcher for the Connecticut School of Integrative Manual Therapy, Dialogues in Contemporary Rehabilitation, and Northeast Seminars. Before that she spent 10 years working as a freelance journalist. 
     Each library includes Healthcare Resources, Advertising, Marketing and Public Relations Resources, Business Resources, International Resources, Education and Distance Learning Resources, Articles, Abstracts, Documents, Papers, Reports and Literature Resources on the following topics:

Matrix Energetics Library and Resource Center
     “One of the things I love about going to Matrix Energetics classes is that it gets my creative juices going and enables me to be more aware of my surrounding. In other words to notice and perceive more. I feel this increases my ability to notice something useful for my clients, my friends, my family and myself. The purpose of the Matrix Energetics Library is the same. We live in the information age,” Kimberly Burnham, Matrix Energetics Librarian.
     “There are 540,000 words in the English language about 5 times as many as in Shakespeare's time. More than 3000 new books are published everyday. It is estimated that a weeks worth of New York Times contains more information than a person in 18th century was likely to come across in a lifetime.” [Full Text Video] http://www.flixxy.com/technology-and-education-2008.htm 
     Accessing some of this information, images, shapes, symbols, people (Whizard’s Council), book reviews, articles, research on modalities that work for people and can be put into a module for the individual client, nutritional and homeopathic information which can be used virtually can make our Matrix Energetics process more interesting.
 Voltaire 1694 - 1778, the famous, controversial French author, humanist, rationalist, satirist and philosopher said, "The art of medicine consists of keeping the patient amused while nature heals the disease." Voltaire is also quoted as saying of the medical establishment of the day, "they poured drugs of which they knew little to cure diseases of which they knew less into human beings of whom they knew nothing." 
     The information in the library is meant to enable Matrix Energetics practitioners to amuse themselves, their clients and change the world in the process.  
     For ten years, Kimberly Burnham, PhD worked as the Director of Knowledge Management and Librarian for the Center for Integrative Manual Therapy and Diagnostics. Before that she worked for 10 years as a freelance journalist. She has practiced, taught, written and read widely in the field of health and wellness in the last 30 years.
     She has been Matrix Energetics certified since 2008 and is a Matrix Energetics librarian with access to a vast library of reference images, material and information on ways in which people can feel better and function better.
     She will be putting on a series of free Matrix Energetics practice groups to explore the library and find more ways to visualize health and well being.
     The practice groups are available free on a first come first serve basis. Sign up for our monthly email letter for information on topics and dates and let us know you are interested.
     These are accessed through skype and teleconference.
     The practice groups are open to anyone who has taken a Matrix Energetics course

     The first in the series will be
Friday  April 23, 2010   6:30 - 8 pm at Mission Hills Physical Therapy and on Skype. The topic is: Noticing and Feeling Frequencies, Numbers, Shapes, Layers, Levels and More

Other topics that will be covered in the future are:
- Integrating Matrix Energetics and Homeopathy, Supercharging Your Current Nutritional Knowledge
- Matrix Energetics Two Point Process and Integrative Manual Therapy's Templates
- Manual Therapists Access Positive Outcomes by Collapsing the Matrix Energetics Wave
- Matrix Energetics's Copies, Dowsing and Treatment Planning
- Visualizing and Shifting Time and Space

 Kimberly Burnham, PhD Matrix Energetics Certified is working towards certification as a Matrix Energetics Study Group Leader. She will be doing a series of practice groups free of charge. The first of which will be in San Diego, CA at Mission Hills Physical Therapy with Ralph Havens, PT Matrix Energetics Certified.

 Starting in September, 2010 by which time she expects to be a certified Matrix Energetics Study Group leader she will continue to hold study groups and explore topics in the library.
 She also does consultation on any health and wellness topic. See below for services and samples available.

[Click Here To See a Sample Page] Time Page

Integrative Manual Therapy Library and Resource Center
 The Integrative Manual Therapy Library houses several thousand book (many of which are reviewed) and tens of thousands of articles available for Integrative Manual Therapy practitioners as well as students at the Connecticut School of Integrative Manual Therapy who are completing research on case studies or need information for their clients on a particular conditions and how it relates to advanced manual therapy practices.
 Kimberly Burnham, PhD in Integrative Medicine and IMTC taught for many years at the Connecticut School of Integrative Manual Therapy, Dialogues in Contemporary Rehabilitation (DCR), and Northeast Seminars both in the United States and Internationally.
 She is a Certified Integrative Manual Therapist and Requirements can be met with her for Observation and Treatment hours with an Integrative Manual Therapist, Certified (I.M.T.,C).
 Kim is also the author of the Neuroantomy course for Integrative Manual Therapy Practitioners.

[Click Here To See a Sample Page] Bone Disorders Page

Reference material for the Connecticut School of Integrative Manual Therapy's Integrated Systems Approach includes the following systems and more:
1. System of Biomechanics (joint integrity of the pelvis, sacrum, spine, and peripheral joints)
2. Musculoskeletal System
3. Connective Tissue System
4. Central Nervous System (brain and spinal cord)
5. Cranial System
6. Peripheral Nervous System
7. Visceral System (cardiac, digestive, urogenital, immune, pulmonary, detoxification, and more)
8. Circulatory Systems (arterial, venous, and lymphatic)
9. System of Energy
10. Body/Mind Systems

The information comes from the Morphic Field of medical doctors, physical therapists,
chiropractors, occupational therapists, massage therapists, speech therapists, physicians, learning
specialists, psychologists, nurses, wellness experts in body work, and more.

It is produced by practitioners in hospitals, outpatient clinics, schools, universities as well as other institutions.

IMT addresses rehabilitation in two categories: Structural Rehabilitation and Functional
Rehabilitation.
Structural Rehabilitation improves structural integrity of the body. It addresses joint
mobility, muscle tone, soft tissue flexibility, range of motion, muscle control and more. It
corrects patho-anatomy in biomechanics of the spine and appendages, muscles, connective
tissue system, organs, nervous system, blood vessels, lymphatic system and energetic
structures.
Functional Rehabilitation restores functional outcomes according to the optimal potential
of the client. It addresses balance, coordination, proprioception (internal joint sensation),
exteroception (sensory capability), strength, endurance, hearing, vision, speech, smell,
learning, behavior and more.
Structural Rehabilitation corrects anatomic dysfunction and influences physiology. It
creates the potential for function. Functional Rehabilitation optimizes the patient's
utilization of this function. The relationship between Structural and Functional
Rehabilitation can be illustrated in the following analogy. Think of a child playing the
piano. If the piano is out of tune, the music will sound poor. Even if the child is a master
prodigy of the piano, the music will still sound poor because the structural integrity of the
piano is lacking. It is always more efficient and effective to treat structure first - to tune
the piano. Once the piano is tuned, the potential for good music is there, but the child may
require some lessons. These lessons are Functional Rehabilitation. This Functional
Rehabilitation will help the child to reach his/her potential in creating beautiful music.

A Summary
There is no 'one' single problem affecting a person, causing disability and pain, and
inhibiting their function. Persons of all ages, cultures, and locations are composites of
their past, present, and future goals. Emotional, personal, mental/cognitive, spiritual and
other aspects of living contribute to healthy life-styles and goal-oriented function. Persons
around the world are learning more every day about function and dysfunction.
Accountability and responsibility for function and productivity belongs to everyone, rather
than to the physician, the insurance company, and the drug vendor. Integrative Manual
Therapy is more than structural and functional rehabilitation, more than Integrative
Diagnostics, more than an Integrated Systems approach to correct dysfunction and improve
function. It is an ever-expanding field contributing to all disciplines, who wish to improve
home, community, and world health.

 The Integrative Manual Therapy Library includes reference material and journal articles for the following courses and more.

Biophysiography/Functional Nutrition (4 Credits)
BIOPH 201 Physical Functional Medicine (1 day - 1 credit)
BIOPH 301 Functional Medicine/Concepts in Applied Nutrition and Biophysiography
(4 days - 3 credits)

Body/Mind Systems (3 Credits)
BODM 301 Integrative Diagnostics for Applied Psychosynthesis (4 days - 3 credits)

Connective Tissue System (3 Credits)
CTIS 101 Myofascial Release for the Orthopedic, Neurologic, Pediatric and Geriatric Patient:
The 3-Planar Fascial Fulcrum© Approach (3 days - 2 credits)
CTIS 102 Myofascial Mapping©-A Critical Diagnostic Skill for Manual Practitioners
(1 day - 1 credit)

Cranial and Nervous System (12 Credits)
CRNS 101 Cranial Therapy Series, Level One: Osseous, Suture, Joint and Membrane. Treatment
of Headaches and Trauma (3 days - 2 credits)
CRNS 103 Neural Tissue Tension Techniques: Decrease Pain, Increase Movement, Improve Nerve
Function (3 days - 2 credits)
CRNS 201 Cranial Therapy Series, Level Two: Membrane; Fluid; Face; Intra-Oral Dysfunction
(4 days - 3 credits)
CRNS 301 Cranial Therapy Series, Level Three: Pain and Disability; CSF; Spinal Cord and Brain
Fibrosis; Immunology (4 days - 3 credits)
CRNS 401 Cranial Therapy Series, Level Four: Cranial Therapy: Recovery and Rehabilitation
Protocols (3 days - 2 credits)

Immunity and Detoxification: Lymphatic System (4 Credits)
IMDE 101 Lymphatic Series, Level One: Lymph Congestion Therapy (3 days - 2 credits)
IMDE 201 Lymphatic Series, Level Two: Immune Preference (3 days - 2 credits)

Integrated Curriculum in Integrative Manual Therapy (4 Credits)
INTC 201 Double Crush Syndrome: Treatment for Thoracic Outlet Syndrome, Carpal Tunnel and
Upper Extremity Pain and Dysfunction (3 days - 2 credits)
PEDS 101 Pediatric Solutions: An IMT Approach for Comprehensive Assessment and Treatment
(3 days - 2 credits)

Integrative Diagnostics, 4 total credit hours
INTDG 101/201 Integrative Diagnostic Series, Levels One and Two: Myofascial Mapping and
Neurofascial Process (3 days - 3 credits)
INTDG 301 Integrative Diagnostic Series, Level Three: Toxicity, Circulation, Diagnostics
(2 days - 1 credit)

Musculoskeletal System and Biomechanics (13 Credits)
MSKEL 100 Mobility Templates: New and Improved Approach for Treatment of the Pelvis, Sacrum
and Spine with Muscle Energy and 'Beyond' Technique (3 days - 2 credits)
MSKEL 103 Rib Cage Biomechanics with Muscle Energy Technique and 'Beyond' (1 day - 1 credit)
MSKEL 105 Strain and Counterstrain Technique and Advanced Strain Counterstrain Technique. A
Manual Therapy Solution for Protective Muscle Spasm in the Orthopedic, Neurologic, Pediatric,
and Geriatric Patient (4 days - 4 credits)
MSKEL 205 Upper and Lower Extremities Rehabilitation with Compression Syndromes (4 days - 4 credits)
MSKEL 301 The Spine: From Low Back Pain and Cervical Syndrome through Spinal Cord Injury
(3 days - 2 credits)

Protective Modes (2 Credits)
PMOD 101 Diaphragm Compression Syndromes: Comprehensive Manual therapy for Circulation,
Breathing and Pain disorders. A total body approach (3 days - 2 credits)

Visceral and Organ Systems (10 Credits)
VOSYS 201 Gastrointestinal Tract: Pain and Dysfunction. A Manual Therapy Solution
(3 days - 2 credits)
VOSYS 202 Women's and Men's Health: Treatment for Urogenital Pain and Dysfunction
A Manual Therapy Solution. (3 days - 2 credits)
VOSYS 361 Lung Management: Pulmonary Insufficiency and Oxidative Stress
(3 days - 2 credits)
VOSYS 401 Cardiac Habilitation: Prevention and Treatment. A Manual Therapy Solution
(3 days - 2 credits)
VOSYS 501 Cardiovascular Rehabilitation: Combined Vessels Approach (3 days - 2 credits)

Academic/Basic Sciences, 14 total credit hours
Growth and Development - Infant to Adult (3 Credits)
Kinesiology (2 Credits)
Neuroanatomy (3 Credits)
Pathophysiology (3 Credits)
Psychology (3 Credits)

Functional Electives, 10 total credit hours
Alexander Neuro Developmental Treatment (NDT)
Aston Patterning Pilates/Plyometrics
Body Mind Centering PNF
Functional Orthopaedics Sensory Integration
Hellerwork Tai Chi Chuan
Hippo therapy Trager
Yoga