Feel Better / Function Optimally with Integrative Medicine & Manual Therapy
7-22 Connective Tissue Disorders, Ehler-Danlos Syndrome
Connective Tissue Disorders and Manual Therapy
Manual therapy and Massage therapy practitioners, Acupuncturist, Integrative Manual Therapists, Osteopaths and Chiropractors use a variety of techniques to increase circulation and fluid flow, decrease scar tissue and pain, improve joint mobility and strength, reduce depression and eliminate the signs and symptoms of connective tissue and extracellular matrix disorders in the field of fasciology.
They treat clients with a variety of connective tissue dysfunctions including: Benign Joint Hypermobility, Marfan’s syndrome, Ehlers-Danlos syndrome / Cutis Hyperelastica, osteogenesis imperfecta, Scleroderma, Rheumatoid arthritis, Raynaud's phenomenon, mixed connective tissue disease (MCTD), Cardiovascular disorders, Down’s syndrome, metabolic disorders (homocystinuria and hyperlysinemia), Fibromyalgia, Recurrent joint dislocations, Chronic low back pain, Carpal tunnel syndrome and Motor vehicle accident (MVA) injuries.
This issue of The Burnham Review also focuses on the work on Helene Langevin, MD at the University of Vermont Medical School. She describes both the cellular properties of connective tissue and the effects of mechanical stretching and acupuncture in relationship to connective tissue. Many of the articles published by Dr. Langevin are available in full text.
In a recent article, Langevin notes, "a patient presenting with a flareup of ulcerative colitis preceded by a two week exacerbation of knee osteoarthritis would probably be thought to have two distinct problems, one in the gut and one in the knee. Establishing the presence of a connective tissue ‘‘bridge’’ between these two medical problems would potentially have important repercussions on both diagnosis and treatment of these conditions." (Langevin,2006)............Buy This Issue Today
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7-1 Benefits of Touch and NFP, The Burnham Review FREE Today
7-2 Integrative Manual Therapy (IMT) Where Is It Written?, The Burnham Review FREE Today
7-3 A Nutritional Wellness Self Study Program, The Burnham Review
7-4 NeuroAnatomy Study List for Manual Therapists, The Burnham Review
7-5 Manual Therapy and the Peace Process, The Burnham Review
Selected Work Helene M Langevin, MD et al.
1. Langevin, H. M., D. M. Rizzo, et al. (2007). "Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound." BMC Syst Biol 1: 25 [Full Text] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17550618.
2. Langevin, H. M., N. A. Bouffard, et al. (2006). "Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanism." J Cell Physiol 207(3): 767-74 [Full Text] http://drwdowin.com/Research.html.
3. Langevin, H. M. (2006). "Connective tissue: a body-wide signaling network?" Med Hypotheses 66(6): 1074-7 [Full Text] www.anatomytrains.com/uploads/rich_media/c04c7252238ff6f72d81f52c89a20f85.pdf and Anatomy Trains http://www.anatomytrains.com/at/library/articles and Fascia Research Congress http://www.fascia2007.com/presenters.php.
4. Langevin, H. M., N. A. Bouffard, et al. (2005). "Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo." Am J Physiol Cell Physiol 288(3): C747-56 [Full Text] http://ajpcell.physiology.org/cgi/content/full/288/3/C747
5. Ahn, A. C., J. Wu, et al. (2005). "Electrical impedance along connective tissue planes associated with acupuncture meridians." BMC Complement Altern Med 5: 10 [Full Text] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15882468.
6. Langevin, H. M., E. E. Konofagou, et al. (2004). "Tissue displacements during acupuncture using ultrasound elastography techniques." Ultrasound Med Biol 30(9): 1173-83 [Full Text] http://www.bme.columbia.edu/eekweb/journals/2004-eek_umb_displacement.pdf.
7. Langevin, H. M., C. J. Cornbrooks, et al. (2004). "Fibroblasts form a body-wide cellular network." Histochem Cell Biol 122(1): 7-15 [Full Text] http://www.uvm.edu/~annb/faculty/PDFs/7-15.pdf.
8. Iatridis, J. C., J. Wu, et al. (2003). "Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension." Connect Tissue Res 44(5): 208-17 [Full Text] http://www.med.uvm.edu/neurology/downloads/Subcutaneoustissuemechanicalbehavior.pdf.
9. Langevin, H. M. and J. A. Yandow (2002). "Relationship of acupuncture points and meridians to connective tissue planes." Anat Rec 269(6): 257-65 [Full Text] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12467083.
10. Langevin, H. M., D. L. Churchill, et al. (2002). "Evidence of connective tissue involvement in acupuncture." Faseb J 16(8): 872-4 [Full Text] http://www.med.uvm.edu/neurology/downloads/Evidenceofconnectivetissueinvolvementinacupuncture.pdf.
11. Langevin, H. M., D. L. Churchill, et al. (2001). "Biomechanical response to acupuncture needling in humans." J Appl Physiol 91(6): 2471-8 [Full Text] http://www.med.uvm.edu/neurology/Downloads/Biomechanicalresponsetoacupunctureneedlinginhumans.pdf.
12. Langevin, H. M., D. L. Churchill, et al. (2001). "Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture." Faseb J 15(12): 2275-82 [Full Text] http://www.fasebj.org/cgi/content/abstract/15/12/2275.
Highlighted References
1. Chicurel, M. E., C. S. Chen, et al. (1998). "Cellular control lies in the balance of forces." Curr Opin Cell Biol 10(2): 232-9. [Full Text] http://www.seas.upenn.edu/~chenlab/pdf/07_Chicurel98.PDF
2. Still, A. T. (1902). The Philosophy and Mechanical Principles of Osteopathy. Kansas City, Mo, Hudson-Kimberly Publication Co. [Full Text] 322 page e-book http://www.interlinea.org/atstill/eBookPMPO_V2.0.pdf
3. Weiselfish-Giammatteo, S., J. B. Kain, et al. (2005). Integrative manual therapy for the connective tissue system: myofascial release. Berkeley, Calif., North Atlantic Books. http://www.CenterIMT.com
4. Weiselfish-Giammatteo, S. (2000) Disruptions of Membrane. from www.centerimt.com/Products/videos.asp . Bloomfield, CT, Dialogues in Contemporary Rehabilitation.
General References
Public Medline http://www.ncbi.nlm.nih.gov
CAM Research http://www.camresearch.net
1. Langevin, H. M. (2006). "Connective tissue: a body-wide signaling network?" Med Hypotheses 66(6): 1074-7 [Full Text] www.anatomytrains.com/uploads/rich_media/c04c7252238ff6f72d81f52c89a20f85.pdf
2. Wang, J., W. R. Dong, et al. (2007). "[From meridians and acupoints to self-supervision and control system: a hypothesis of the 10th functional system based on anatomical studies of digitized virtual human]." Nan Fang Yi Ke Da Xue Xue Bao 27(5): 573-9. [PubMed Abstract] and Wang, J., C. L. Wang, et al. (2007). "[Explanation of essence and substance basis of channels and collaterals with fasciology]." Zhongguo Zhen Jiu 27(8): 583-5. [PubMed Abstract] and [Abstract] http://www.camresearch.net/showabstract.php?pmid=17853756
3. Simpson, M. R. (2006). "Benign joint hypermobility syndrome: evaluation, diagnosis, and management." J Am Osteopath Assoc 106(9): 531-6. [Full Text] http://www.jaoa.org/cgi/content/full/106/9/531
4. Goats, G. C. and K. A. Keir (1991). "Connective tissue massage." Br J Sports Med 25(3): 131-3. [PubMed Abstract]
5. Michalsen, A. and M. Buhring (1993). "[Connective tissue massage]." Wien Klin Wochenschr 105(8): 220-7 [PubMed Abstract] [Abstract] http://www.camresearch.net/showabstract.php?pmid=8506683.
6. Brattberg, G. and European Federation of Chapters of the International Association for the Study of Pain (1999). "Connective tissue massage in the treatment of fibromyalgia." Eur J Pain 3(3): 235-244 [PubMed Abstract]
7. Still, A. T. (1902). The Philosophy and Mechanical Principles of Osteopathy. Kansas City, Mo, Hudson-Kimberly Publication Co. [Full Text] 322 page e-book http://www.interlinea.org/atstill/eBookPMPO_V2.0.pdf.
8. Lee, R. P. (2006). "Still's concept of connective tissue: lost in "translation"?" J Am Osteopath Assoc 106(4): 176-7; author reply 213-4. [Full Text] http://www.jaoa.org/cgi/content/full/106/4/176 and Sutherland, W. G., DO and D. Ada Strand and Anne Wales, editors, (1998). Contributions of Thought: the Collected Writings of W.G. Sutherland. Fort Worth, Tex, Sutherland Cranial Teaching Foundation; 1998 [Reference] http://www.osteopathic.org/pdf/pub_osteolit.pdf and Rogers, F. J., G. E. D'Alonzo, Jr., et al. (2002). "Proposed tenets of osteopathic medicine and principles for patient care." J Am Osteopath Assoc 102(2): 63-5 [Full Text] http://www.jaoa.org/cgi/reprint/102/2/63.
9. Lee, R. P. (2006). "Still's concept of connective tissue: lost in "translation"?" J Am Osteopath Assoc 106(4): 176-7; author reply 213-4. [Full Text] http://www.jaoa.org/cgi/content/full/106/4/176
10. Lopes, C., A. Manique, et al. (2006). "[Ehlers-Danlos syndrome - a rare cause of spontaneous pneumothorax]." Rev Port Pneumol 12(4): 471-80. [PubMed Abstract]
11. Le Tallec, H., A. Lassalle, et al. (2006). "[Two cases of rehabilitation in Ehler-Danlos syndrome]." Ann Readapt Med Phys 49(2): 81-4. [PubMed Abstract]
12. Cabral, W. A., E. Makareeva, et al. (2005). "Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing." J Biol Chem 280(19): 19259-69. [Full Text] http://www.jbc.org/cgi/content/full/280/19/19259
13. Gaby, A. R. (2006). "Natural remedies for scleroderma." Altern Med Rev 11(3): 188-195. [Full Text] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17217320
14. Langevin, H. M. and J. A. Yandow (2002). "Relationship of acupuncture points and meridians to connective tissue planes." Anat Rec 269(6): 257-65. [Full Text] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12467083
15. Collins, L. (2005). "Healing hands Integrated manual therapy is alternative method of relieving pain." 2005(Sept 17): [Full Text] http://deseretnews.com/dn/view/0,1249,600108104,00.html.
16. Holt, J. (2004). "Manual Therapy and Athletic Injury Rehabilitation: Benefits of a Class of Therapy." The Sport Supplement, A Supplement of the Sports Journal Volume 12, Number 3: Summer [Full Text] http://www.thesportjournal.org/sport-supplement/vol12no3/03manual_therapy.asp
17. Holt, J. (2004). "Manual Therapy and Athletic Injury Rehabilitation: Benefits of a Class of Therapy."
18. Holt, J. (2004). "Manual Therapy and Athletic Injury Rehabilitation: Benefits of a Class of Therapy."
19. Colloca, C. J. and B. S. Polkinghorn (2003). "Chiropractic management of Ehlers-Danlos syndrome: a report of two cases." J Manipulative Physiol Ther 26(7): 448-59.[PubMed Abstract]
20. Citak-Karakaya, I., T. Akbayrak, et al. (2006). "Short and long-term results of connective tissue manipulation and combined ultrasound therapy in patients with fibromyalgia." J Manipulative Physiol Ther 29(7): 524-8. [PubMed Abstract] and [Abstract] http://www.camresearch.net/showabstract.php?pmid=16949941
21. Weiselfish-Giammatteo, S., J. B. Kain, et al. (2005). Integrative manual therapy for the connective tissue system: myofascial release. Berkeley, Calif., North Atlantic Books. http://www.CenterIMT.com
22. Giammatteo, S. (2000). What is Integrative Manual Therapy and How Does it Relate to Knee Injuries: from http://www.centerimtboulder.com/sportsinjuries_article1.htm.
23. Giammatteo, S. (2000). What is Integrative Manual Therapy and How Does it Relate to Knee Injuries:
24. Valentiner, U., M. Weiser, et al. (2003). "The effect of homeopathic plant extract solutions on the cell proliferation of human cutaneous fibroblasts in vitro." Forsch Komplementarmed Klass Naturheilkd 10(3): 122-7. [PubMed Abstract]
25. Tsukanov Iu, T. and A. Tsukanov (2004). "[Varicosis of the lower extremities as a consequence of connective tissue dysplasia]." Angiol Sosud Khir 10(2): 84-9. [PubMed Abstract]
26. Kanazawa, M., Y. Wada, et al. (2004). "Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report." Clin Rheumatol 23(5): 456-9. [PubMed Abstract]
27. Yen, J. L., S. P. Lin, et al. (2006). "Clinical features of Ehlers-Danlos syndrome." J Formos Med Assoc 105(6): 475-80.
28. Weiselfish-Giammatteo, S. (2000) Disruptions of Membrane. from www.centerimt.com/Products/videos.asp. Bloomfield, CT, Dialogues in Contemporary Rehabilitation. http://www.CenterIMT.com
29. Storch, K. N., D. J. Taatjes, et al. (2007). "Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblasts." Histochem Cell Biol 127(5): 523-30. [PubMed Abstract]
30. Adcocks, C., P. Collin, et al. (2002). "Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro." J Nutr 132(3): 341-6. [Full Text] http://jn.nutrition.org/cgi/content/full/132/3/341
31. Curtis, C. L., S. G. Rees, et al. (2002). "Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids."ArthrRheum46(6):1544-53. [Full Text] retracted http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12115185
32. Hankenson, K. D., B. A. Watkins, et al. (2000). "Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production." Proc Soc Exp Biol Med 223(1): 88-95. [Full Text] http://www.ebmonline.org/cgi/content/full/223/1/88
33. Yousefi-Nooraie, R., E. Schonstein, et al. (2007). "Low level laser therapy for nonspecific low-back pain." Cochrane Database Syst Rev(2): CD005107. [Abstract] http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD005107/frame.html
34. Luminex Medical Laser System 4 different heads with laser diodes of an average power of 500mW at a wavelength of 867nm[Full Text] www.medicallasersystems.com
35. Mojzis L, Nemec R, Hlavaty V. Children of Your Own: the Mojzis Method. Boulder, Colo: Richmond Bay; 1990. and (Volejnikova,2001). Volejnikova H. Female infertility: a study of physical treatment by the method of L. Mojzisov for functional disturbances of the pelvic region. J Orthopaedic Med. 2001;23:47-49.
36. Wurn, B. F., L. J. Wurn, et al. (2004). "Treating Female Infertility and Improving IVF Pregnancy Rates With a Manual Physical Therapy Technique." Medscape General Medicine 6(2):51: [Full Text] http://www.medscape.com/viewarticle/480429_print and www.clearpassage.com
37. Langevin, H. M. and K. J. Sherman (2007). "Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms." Med Hypotheses 68(1): 74-80. [Full Text] www.chiro.org/LINKS/ABSTRACTS/Pathophysiological_Model_for_Chronic_Low_Back_Pain.shtml
38. Dr. Dan Murphy,DC from [Full Text] www.chiro.org/LINKS/ABSTRACTS/Pathophysiological_Model_for_Chronic_Low_Back_Pain.shtml
39. Warren, H (2006) Fibrosis May Be Related to Chronic Pain http://www.warrenhammer.com and www.chiroweb.com/columnist/hammer
40. Warren, H (2006) Fibrosis May Be Related to Chronic Pain http://www.warrenhammer.com
41. Humphreys, B. K., S. Kenin, et al. (2003). "Investigation of connective tissue attachments to the cervical spinal dura mater." Clin Anat 16(2): 152-9. [PubMed Abstract]
42. Ahn, A. C., J. Wu, et al. (2005). "Electrical impedance along connective tissue planes associated with acupuncture meridians." BMC Complement Altern Med 5: 10. [Full Text] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15882468
43. Brown, D. P. (2007). "The Energy Body and Its Functions: Immunosurveillance, Longevity, and Regeneration." Ann N Y Acad Sci. [Abstract] http://www.camresearch.net/showabstract.php?pmid=17905935
44. Langevin, H. M., N. A. Bouffard, et al. (2006). "Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction based mechanism." J Cell Physiol 207(3): 767-74. [Full Text] http://drwdowin.com/Research.html
45. Chicurel, M. E., C. S. Chen, et al. (1998). "Cellular control lies in the balance of forces." Curr Opin Cell Biol 10(2): 232-9. [Full Text] http://www.seas.upenn.edu/~chenlab/pdf/07_Chicurel98.PDF
46. Giancotti, F. G., Ruoslahti, E. (1999) Integrin signaling. Science 285,1028-1032 [Full Text] http://www.sciencemag.org/cgi/content/abstract/285/5430/1028?ijkey=61ec39623ca419e89a29e55d4dce4dad1d93edb6&keytype2=tf_ipsecsha
47. Burridge, K., Fath, K., Kelly, T., Nuckolls, G., Turner, C. (1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4,487-525
48. Muller, J. M., Chilian, W. M., Davis, M. J. (1997) Integrin signaling transduces shear stress-dependent vasodilatation of coronary arterioles. Circ. Res. 80,320-326 [Full Text] http://circres.ahajournals.org/cgi/content/full/80/3/320?ijkey=5b507f251758363034d127ceb355c7babf84809a
49. Clark, E. A., Brugge, J. S. (1995) Integrins and signal transduction pathways: the road taken. Science 268,233-239 [Full Text] http://www.sciencemag.org/cgi/content/abstract/268/5208/233?ijkey=3ac4cbb92d7d33ab01005d747add96aa7b2c9c5f&keytype2=tf_ipsecsha
50. Banes, A. J., Tsuzaki, M., Yamamoto, J., Fischer, T., Brigman, B., Brown, T., Miller, M. (1995) Mechanoreception at the cellular level: the detection, interpretation and diversity of responses to mechanical signals
51. Banes, A. J., Tsuzaki, M., Yamamoto, J., Fischer, T., Brigman, B., Brown, T., Miller, M. (1995) Mechanoreception at the cellular level: the detection, interpretation and diversity of responses to mechanical signals. Biochem. Cell Biol. 73,349-365.
52. Dartsch, P. C., Hammerle, H. (1986) Orientation response of arterial smooth muscle cells to mechanical stimulation. Eur. J. Cell Biol. 41,339-346
53. Sumpio, B. E., Banes, A. J., Buckley, M., Johnson, G. (1988) Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. J. Vasc. Surg. 7,130-138.
54. Sumpio, B. E., Banes, A. J., Buckley, M., Johnson, G. (1988) Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. J. Vasc. Surg. 7,130-138
55. Harris, A. K., Wild, P., Stopak, D. (1980) Silicone rubber substrata: a new wrinkle in the study of cell locomotion. Science 208,177-179. [Full Text] http://www.sciencemag.org/cgi/content/abstract/208/4440/177?ijkey=3fc4fd3eee0db9f991198c90f73f8755d3dc832d&keytype2=tf_ipsecsha
56. Langevin, H. M., D. L. Churchill, et al. (2001). "Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture." Faseb J 15(12): 2275-82. [Full Text] http://www.fasebj.org/cgi/content/abstract/15/12/2275
57. Bouffard, N.A., K. R.Cutroneo, et al.(2007)."Tissue stretch decreases soluble TGF-beta1 and type-1 procollagen in mouse subcutaneous connective tissue: "J Cell Physiol.[PubMed Abstract]
58. Langevin, H. M., D. M. Rizzo, et al. (2007). "Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound." BMC Syst Biol 1: 25. [Full Text] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17550618
59. Langevin, H. M. (2006). "Connective tissue: a body-wide signaling network?" Med Hypotheses 66(6): 1074-7. [Full Text] Anatomy Trains http://www.anatomytrains.com/at/library/articles and Fascia Research Congress http://www.fascia2007.com/presenters.php
60. Langevin, H. M., K. N. Storch, et al. (2006). "Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actin." Histochem Cell Biol 125(5): 487-95. [PubMed Abstract]
61. Langevin, H. M., N. A. Bouffard, et al. (2007). "Connective tissue fibroblast response to acupuncture: dose-dependent effect of bidirectional needle rotation." J Altern Complement Med 13(3): 355-60. [Abstract] http://www.acupuncture.com/newsletters/m_jun07/res.htm#1
62. Langevin, H. M., N. A. Bouffard, et al. (2005). "Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo." Am J Physiol Cell Physiol 288(3): C747-56. [Full Text] http://ajpcell.physiology.org/cgi/content/full/288/3/C747 and Langevin HM, Churchill DL, and Cipolla MJ. Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture. FASEB J 15: 2275–2282, 2001. and Langevin HM, Churchill DL, Wu J, Badger GJ, Yandow J, Fox JR, and Krag MH. Evidence of connective tissue involvement in acupuncture. FASEB J 16: 872–874, 2002.
63. Langevin, H. M., N. A. Bouffard, et al. (2007). "Connective tissue fibroblast response to acupuncture: dose-dependent effect of bidirectional needle rotation." J Altern Complement Med 13(3): 355-60. [Abstract] http://www.acupuncture.com/newsletters/m_jun07/res.htm#1
64. Ready, Darren Wellcome (2007) [Image] http://www.wellcome.ac.uk/en/bia/gallery.html?image=6)
65. Tabeta, K., H. Yoshie, et al. (2001). "Characterization of serum antibody to Actinobacillus actinomycetemcomitans GroEL-like protein in periodontitis patients and healthy subjects." Oral Microbiol Immunol 16(5): 290-5. [PubMed Abstract]
66. Hirota,K., H.Kanitani,et al.(1995)."Cross-reactivity between human sialyl Lewis(x) oligosaccharide and common causative oral bacteria of infective endocarditis." FEMS Immunol Med Microbiol 12(2): 159-64. [PubMed Abstract]
67. Mintz, K. P. (2004). "Identification of an extracellular matrix protein adhesin, EmaA, which mediates the adhesion of Actinobacillus actinomycetemcomitans to collagen." Microbiology 150(Pt 8): 2677-88. [Full Text] http://mic.sgmjournals.org/cgi/content/full/150/8/2677?view=long&pmid=15289564
68. Ruiz, T., C. Lenox, et al. (2006). "Novel surface structures are associated with the adhesion of Actinobacillus actinomycetemcomitans to collagen." Infect Immun 74(11): 6163-70. [Full Text] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17057091
69. Patti, J. M., Allen, B. L., McGavin, M. J. & Hook, M. (1994). MSCRAMM-mediated adherence of microorganisms to host tissues. Annu Rev Microbiol 48, 585–617. [PubMed Abstract]
70. Mintz, K. P. (2004). "Identification of an extracellular matrix protein adhesin, EmaA, which mediates the adhesion of Actinobacillus actinomycetemcomitans to collagen." Microbiology 150(Pt 8): 2677-88. [Full Text] http://mic.sgmjournals.org/cgi/content/full/150/8/2677?view=long&pmid=15289564