7-01 Agenesis of the Corpus Callosum, Aicadia Syndrome Can Cranial Therapy Help?

      Sometimes people with agenesis [lack of development] of the corpus callosum [the area of the brain which connects the right and left sides] are “only slightly impaired relative to normal subjects” (Forster, 2000). Agenesis of the corpus callosum can be associated with hemangiomas, brain abnormalities, cranial cysts, cranial deformities, arterial dysfunction, eye abnormalities, myelination problems, autonomic nervous system, and olfactory bulb dysfunctions. 
      Manual Therapy approaches including Cranial Therapy, Integrative Manual Therapy and Osteopathic Manual Therapy have helped address the function in many children with brain dysfunctions. The purpose of this review is to give a skilled manual therapist, not familiar with agenesis of the corpus callosum, an idea about the different anatomic presentations and clinical considerations............Buy This Issue Today

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– Riley, E. P. and C. L. McGee (2005). "Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior." Exp Biol Med (Maywood) 230(6): 357-65.

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2. Drosou, A., Benjamin, L., Linfante, I., Mallin, K., Trowers, A., Wakhloo, A. K., et al. (2006). Infantile midline facial hemangioma with agenesis of the corpus callosum and sinus pericranii: another face of the PHACE syndrome. J Am Acad Dermatol, 54(2), 348-352.

3. Tange, Y., Aoki, A., Mori, K., Niijima, S., & Maeda, M. (2000). Interhemispheric glioependymal cyst associated with agenesis of the corpus callosum--case report. Neurol Med Chir (Tokyo), 40(10), 536-542.

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6. Ng, Y. T., McCarthy, C. M., Tarby, T. J., & Bodensteiner, J. B. (2004). Agenesis of the corpus callosum is associated with feeding difficulties. J Child Neurol, 19(6), 443-446.

7. Nakamura, N., Ogawa, A., Kayama, T., Sakurai, Y., Yoshimoto, T., & Suzuki, J. (1986). [A case of agenesis of the corpus callosum accompanied by a ruptured azygos anterior cerebral artery aneurysm and lipoma--a case report]. No To Shinkei, 38(7), 701-705.

8. Delaney, J. P., K. S. Leong, et al. (2002). "The short-term effects of myofascial trigger point massage therapy on cardiac autonomic tone in healthy subjects." J Adv Nurs 37(4): 364-71.

9. Mackay, N., S. Hansen, et al. (2004). "Autonomic nervous system changes during Reiki treatment: a preliminary study." J Altern Complement Med 10(6): 1077-81.

10. Segeren, C. M., Polderman, K. H., & Lips, P. (1997). Agenesis of the corpus callosum associated with paroxysmal hypothermia: Shapiro's syndrome. Neth J Med, 50(1), 29-35.

11. Giammatteo, T. and S. Weiselfish-Giammatteo (1997). Integrative manual therapy for the autonomic nervous system and related disorders : utilizing advanced strain and counterstrain technique. Berkeley, Calif., North Atlantic Books. www.CenterIMT.com

12. Hirayama, K., Hoshino, Y., Kumashiro, H., & Yamamoto, T. (1994). Reverse Shapiro's syndrome. A case of agenesis of corpus callosum associated with periodic hyperthermia. Arch Neurol, 51(5), 494-496.

13. Burnham, K. (2006). The Effect of Integrative Manual Therapy on the symptoms of Parkinson's disease, PhD Dissertation (August 2006) Westbrook University.

14. LeWitt, P. A., R. P. Newman, et al. (1983). "Episodic hyperhidrosis, hypothermia, and agenesis of corpus callosum." Neurology 33(9): 1122-9.

15. Naruse, I., & Keino, H. (1993). Induction of agenesis of the corpus callosum by the destruction of anlage of the olfactory bulb using fetal laser surgery exo utero in mice. Brain Res Dev Brain Res, 71(1), 69-74.

16. Akhtar, S., Bron, A. J., Meek, K. M., & Bennett, K. (2001). Congenital hereditary endothelial dystrophy and band keratopathy in an infant with corpus callosum agenesis. Cornea, 20(5), 547-552.

17. Corballis, M. C. (1998). Interhemispheric neural summation in the absence of the corpus callosum. Brain, 121 ( Pt 9), 1795-1807.

18. Mauersberger, W., & Diaz, L. A. (1985). Sphenopharyngeal encephalocele associated with agenesis of the corpus callosum. Neurochirurgia (Stuttg), 28(6), 238-242.

19. Huang, W. L., Harper, C. G., Evans, S. F., Newnham, J. P., & Dunlop, S. A. (2001). Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep. Int J Dev Neurosci, 19(4), 415-425.

20. Habib, M. (1998). [Corpus callosum disconnection syndromes and functional organization or the corpus callosum in adults]. Neurochirurgie, 44(1 Suppl), 102-109.

21. Buklina, S. B. (2005). The corpus callosum, interhemisphere interactions, and the function of the right hemisphere of the brain. Neurosci Behav Physiol, 35(5), 473-480.

22. Sauerwein, H. C., & Lassonde, M. (1994). Cognitive and sensori-motor functioning in the absence of the corpus callosum: neuropsychological studies in callosal agenesis and callosotomized patients. Behav Brain Res, 64(1-2), 229-240.

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24. DeMarco, P. (1992). Tuberous sclerosis, agenesis of the corpus callosum and Lennox-Gastaut syndrome: mere chance or a new syndrome? Clin Electroencephalogr, 23(1), 7-9.

General References

1. Aiello, I., Sotgiu, S., Sau, G. F., Manca, S., Conti, M., & Rosati, G. (1994). Long latency evoked potentials in a case of corpus callosum agenesia. Ital J Neurol Sci, 15(9), 497-505.

2. Bergada, C., Heinrich, J. J., & Cullen, M. (1969). [Congenital anterior pituitary insufficiency with absence of the corpus callosum. Response to human somatotropin]. Medicina (B Aires), 29(4), 269-273.

3. de Villiers, J. C., Cluver, P. F., & Peter, J. C. (1991). Lipoma of the corpus callosum associated with frontal and facial anomalies. Acta Neurochir Suppl (Wien), 53, 1-6.

4. Gershoni-Baruch, R., Nachlieli, T., & Guilburd, J. N. (1991). Apert's syndrome with occipital encephalocele and absence of corpus callosum. Childs Nerv Syst, 7(4), 231-232.

5. Heene, R. (1966). [Clinical studies on defects of the corpus callosum]. Dtsch Z Nervenheilkd, 188(1), 62-69.

6. Horita, H., Kumagai, K., Maekawa, K., & Endo, S. (1980). Overnight polygraphic study of agenesis of the corpus callosum with seizures resembling infantile spasms. Brain Dev, 2(4), 379-386.

7. Kang, W. M., Huang, C. C., & Lin, S. J. (1992). X-linked recessive inheritance of dysgenesis of corpus callosum in a Chinese family. Am J Med Genet, 44(5), 619-623.

8. Kiley, V. A., & Lazerson, J. (1986). Agenesis of the corpus callosum and neural crest tumors. Pediatr Hematol Oncol, 3(2), 179-182.

9. Lassonde, M., Bryden, M. P., & Demers, P. (1990). The corpus callosum and cerebral speech lateralization. Brain Lang, 38(2), 195-206.

10. LeWitt, P. A., Newman, R. P., Greenberg, H. S., Rocher, L. L., Calne, D. B., & Ehrenkranz, J. R. (1983). Episodic hyperhidrosis, hypothermia, and agenesis of corpus callosum. Neurology, 33(9), 1122-1129.

11. Mohapatro, A. K., Jain, S., Maheshwari, M. C., & Goulatia, R. K. (1990). Corpus callosum agenesis and uncinate seizures. J Assoc Physicians India, 38(5), 371-372.

12. Niwa, J., Okuyama, T., Shimizu, K., & Hirai, H. (1991). [Glio-ependymal cyst in the lateral ventricle complicated by agenesis of the corpus callosum]. No Shinkei Geka, 19(4), 359-363.

13. Sasabe, T., & Iwata, Y. (1969). [Craniolacunia associated with myelomeningocele, hydrocephalus, a huge cavum septi pellucidi, and hypoplasia of the corpus callosum: report of a case]. No To Shinkei, 21(2), 205-209.

14. Schiavetto, A., Lepore, F., & Lassonde, M. (1993). Somesthetic discrimination thresholds in the absence of the corpus callosum. Neuropsychologia, 31(7), 695-707.

15. Steinbrugger, B., & Kurz, R. (1983). ["Essential hypernatremia" as a result of on increased osmoreceptor threshold in a boy with Pierre-Robin disease and corpus callosum agenesis]. Padiatr Padol, 18(2), 181-185.

16. Sugishita, M., Toyokura, Y., Yoshioka, M., & Yamada, R. (1980). Unilateral agraphia after section of the posterior half of the truncus of the corpus callosum. Brain Lang, 9(2), 215-225.

17. Sugishita, M., Yamada, R., & Yoshioka, M. (1975). [Agraphia of the left and after section of the posterior half of the trunk of the corpus callosum]. Rinsho Shinkeigaku, 15(4), 218-225.