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Lyme disease, Borrelia, Manual Therapy
8-21 Lyme Disease, Borrelia, the Extracellular Matrix and Manual Therapy 

In cases of Lyme disease or Borreliosis, there is evidence for the use of manual therapy (Integrative Manual Therapy, Qigong, Massage, Trigger Point Therapy) herbs, energetic methods, ozone, hyperbaric oxygen, Homeopathy (classical, HEEL compound remedies, Sanum pleomorphic remedies),  neurotransmitter balancing, parasympathetic recovery, detox, support, Vitamin D balance, building emotionally and physically, color,  meditation, scenar, LED and laser, Heavy Metal protocols, manual chelation therapy, and more...........Buy This Issue Today
Amazon Editorial Reviews

Lab 257 by Michael Christopher Carroll

"That the United States government engaged in dangerous biological research during World War II will come as no surprise to Americans jaded by revelations of secret medical experiments and radiation exposures. But that the accident-plagued facility where it happened--and continues to happen--is just off the coast of Long Island may alarm many readers of Michael Christopher Carroll's Lab 257. Carroll, an attorney by trade, gamely takes on complex microbiology and shady government record-keeping in telling the story of Plum Island, home of the Animal Disease Center--no place for a casual picnic. The lab, initially set up by the Army to research ways of destroying Soviet farm animals (and to keep them from destroying ours), has often dealt with bacteria and viruses that can be passed from animals to humans. Carroll draws compelling causal links between Plum Island and the introduction of Lyme disease, West Nile virus, and duck enteritis, all non-native germs that wreaked sudden havoc in North America, and all germs that Plum Island scientists were allegedly working with. With hurricanes and terrorists on his mind, Carroll asks readers to imagine a scenario in which the Plum Island lab might release pathogens into the most densely populated area in the country. He ends the book with two chilling questions. First, does the United States need a research facility that investigates animal pathogens with potential for human transmission? Second, considering that Plum Island never had a particularly good safety record, is it the right place for such a facility? Lab 257, while occasionally veering into unsupported speculation, introduces key questions to the debate on biological security in the 21st century." --Therese Littleton

From Publishers Weekly
"This strong first effort by New York lawyer Carroll centers on a U.S. government biological research center devoted to studying such exotic and virulent diseases as African swine fever, Rift Valley fever, foot-and-mouth disease and West Nile virus. Plum Island is quietly nestled a mere two miles off of Long Island, 85 miles from New York City, and Carroll argues convincingly that the island is dangerously insecure. Based on sedulous research into declassified government files and interviews with Plum Island scientists and employees, he offers clear and convincing evidence that Plum Island is rife with the potential for a catastrophic disaster eith?r from an accident or, equally frightening, terrorist action. Carroll raises two chilling questions: Is there a connection between Lyme disease and Plum Island research? (Old Lyme, Conn., the location of the disease's initial 1975 outbreak, is close to Plum Island.) And what about West Nile virus, which also suddenly appeared in close proximity to Plum Island? Carroll offers clear descriptions of the dangers inherent in studying deadly viruses that could infect untold numbers of humans, disrupt the food supply or cripple an entire industry—dangers heightened by a lack of even minimally adequate security. The author acknowledges that the times demand that the U.S. have a research facility like the one at Plum Island and ends this provocative book with a list of reasonable, well-conceived suggestions on how to make the research lab safe, or at least safer. Readers will hope that someone takes notice. 16 pages of b&w photos not seen by PW. "

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General References

[PubMed Abstracts]
http://www.ncbi.nlm.nih.gov

1. ------ (2007). "Lyme Natural Health Care." [Full Text] http://health.groups.yahoo.com/group/lyme-naturalhealthcare/.
    Herbs, energetic methods, ozone, homeopathy, oxygen, sanum remedies, neurotransmitter balancing, parasympathetic recovery, detox, support, building emotionally and physically, color, chi gong, meditation, scenar, LED and laser, Heavy Metal protocols,etc

2. ------ (2007). "Lyme Disease Remedies." The New England Journal of Homeopathy: [Reference] http://www.nesh.com.
    Remedies for Lyme Disease: Mercurius, Lachesis, Spigelia, Euphorbium, Natrum muriaticum , Apis from
Vol 7 #1 Lyme Disease Lyme with the Desire to Kill Rotundo, Beth Case Mercurius
Vol 7 #1 Lyme Disease A Subacute Case of Lyme Disease Guess, George MD DHt Case Lachesis
Vol 7 #1 Lyme Disease Trigeminal Neuralgia and Palpitations from Lyme Disease Fine, Howard ND Case Spigelia
Vol 7 #1 Lyme Disease A Small Remedy in (Alleged) Lyme Disease in a Dog Levy, Jeff DVM Case / Vet Homeo. Euphorbium
Vol 9 #2 Lyme Disease If you Hear Hoofbeats, Don't Think Zebras - A Case of Chronic Lyme Disease Rothenberg, Amy ND DHANP Case Natrum muriaticum
Vol 7 #1 Lyme Disease / Diarrhea Ticked Off by a Tick Malerba, Larry DO Case Apis
Vol 7 #1 Lyme Disease / Neuralgia A Case of a Lyme Related Neuropathy Malerba, Larry DO Case Spigelia

3. Bransfield, R. C., J. S. Wulfman, et al. (2007). "The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders." Med Hypotheses. [Full Text] http://www.lymeinducedautism.com/images/TBILB_Autism.pdf
    Chronic infectious diseases, including tick-borne infections such as Borrelia burgdorferi may have direct effects, promote other infections and create a weakened, sensitized and immunologically vulnerable state during fetal development and infancy leading to increased vulnerability for developing autism spectrum disorders. A dysfunctional synergism with other predisposing and contributing factors may contribute to autism spectrum disorders by provoking innate and adaptive immune reactions to cause and perpetuate effects in susceptible individuals that result in inflammation, molecular mimicry, kynurenine pathway changes, increased quinolinic acid and decreased serotonin, oxidative stress, mitochondrial dysfunction and excitotoxicity that impair the development of the amygdala and other neural structures and neural networks resulting in a partial Kluver-Bucy Syndrome and other deficits resulting in autism spectrum disorders and/or exacerbating autism spectrum disorders from other causes throughout life. Support for this hypothesis includes multiple cases of mothers with Lyme disease and children with autism spectrum disorders; fetal neurological abnormalities associated with tick-borne diseases; similarities between tick-borne diseases and autism spectrum disorder regarding symptoms, pathophysiology, immune reactivity, temporal lobe pathology, and brain imaging data; positive reactivity in several studies with autistic spectrum disorder patients for Borrelia burgdorferi (22%, 26% and 20-30%) and 58% for mycoplasma; similar geographic distribution and improvement in autistic symptoms from antibiotic treatment. It is imperative to research these and all possible causes of autism spectrum disorders in order to prevent every preventable case and treat every treatable case until this disease has been eliminated from humanity. (Bransfield,2007).

4. Cabello, F. C., H. P. Godfrey, et al. (2007). "Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix." Trends Microbiol 15(8): 350-4. [PubMed Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17600717
    Borrelia burgdorferi, the tick-transmitted etiologic agent of Lyme borreliosis, can colonize and persist in multiple tissue sites despite vigorous host immune responses. The extracellular matrix appears to provide a protective niche for the spirochete. Recent studies in mice suggest that B. burgdorferi interacts in various ways with collagen and its associated molecules, exploiting molecular and structural features to establish microcolonial refugia. Better knowledge of the genetic and structural bases for these interactions of B. burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved. Center For Complex Infectious Diseases www.ccid.org

5. Craig-Mylius, K., G. F. Weber, et al. (2005). "Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response." J Leukoc Biol 77(5): 710-8 [Full Text] http://www.jleukbio.org/cgi/content/full/77/5/710.

6. Dommerholt, J. (2007). "Myofascial Trigger Points: An Evidence-Informed Review." Bethesda Physiocare: [Full Text] http://www.bethesdaphysiocare.com/professionals/pdf/jmmt_mtrp-evidencereview_06.pdf
    Clinically, physical therapists should address all aspects of the dysfunction. There are many other conditions that feature muscle pain and MTrPs, including hypothyroidism, systemic lupus erythematosis, Lyme disease, babesiosis, ehrlichiosis, candida albicans infections, myoadenylate deaminase deficiency, hypoglycaemia, and parasitic diseases such as fascioliasis, amoebiasis, and giardia. Therapists should be familiar with the symptoms associated with these medical diagnoses.

7. Foster, J., P. Kane, et al. (2002). "The Detoxx System: Detoxification of Biotoxins in Chronic Neurotoxic Syndromes." Mercola Newsletter: [Full Text] http://findarticles.com/p/articles/mi_m0ISW/is_2002_Nov/ai_93736413.

8. Hodara, S. (2007). "Practitioners striving for innovative options, better treatment, new hope." Special to the Journal News(March 25): [Full Text] www.thejournalnews.com/apps/pbcs.dll/article?AID=/20070325/BUSINESS01/703250302/-1/SPECIAL08
    Hyperbaric Oxygen and Integrative Manual Therapy
It is not the medical profession as a whole that moves health care into the future, but the individual practitioners within it. It is they who explore revolutionary treatments and powerful new drugs, who ennoble patient care and increase the chances that those who are ill will be cured. Driven by personal commitment, these individuals research advances in their fields, and initiate programs and procedures that reflect their knowledge. Their efforts benefit us all.
    Following are five area medical professionals whose pioneering work offers patients of all ages with a variety of health problems new treatment options and new hope.
    Dr. Giuseppina Benincasa-Feingold, Owner, Valley Health, Mahopac
    Ten years ago, when Dr. Giuseppina (Jo) Benincasa-Feingold, an emergency room pediatrician, gave birth to her second daughter, Elisa, her professional path veered toward where it is today. Elisa was born with cerebral palsy, and, Feingold said, "I had to find a way to help her."
    After three years of physical and occupation therapies, Feingold, who by then had had triplets, enrolled Elisa in a cerebral palsy study using hyperbaric oxygen therapy. HBOT is a treatment that saturates the body with oxygen while the patient lies in a cylindrical chamber. Other than ear symptoms similar to those experienced on an airplane, the patient is comfortable, and can spend the one- to two-hour sessions napping or watching television. HBOT is traditionally used for such conditions as carbon monoxide poisoning, decompression sickness, radiation tissue damage, and burns.
    Feingold was struck by the changes in her daughter. "When we started, Elisa spoke about 30 words," she recalled. "We did 120 treatments between December 1999 and April 2000, and by July, her vocabulary had grown to over 1,000 words."
    In 2001, she opened Valley Health, now located in Mahopac, where she uses HBOT to treat an assortment of conditions including cerebral palsy, autism, chronic Lyme disease, chronic fatigue syndrome, migraines and cluster headaches, and brain injuries.

9. Klinghardt, D. (2002). "The Klinghardt Neurotoxin Elimination Protocol." Explore Issue: Volume 12, Number 2: [Full Text] http://www.explorepub.com/articles/summaries/12_2_klinghardt.html
    Biotoxins: such as tetanus toxin, botulinum toxin (botox), ascaridin (from intestinal parasites), unspecified toxins from streptococci, staphylococci, lyme disease, clamydia, tuberculosis, fungal toxins and toxins produced by viruses. Biotoxins are minute molecules (200-1000 kilodaltons) containing nitrogen and sulfur. They belong to a group of chemical messengers which microorganisms use to control the host´s immune system, host behaviour and the host´s eating habits.

10. Klotter, J. (2007). "Lyme Disease." Townsend Letter for Doctors and Patients(April): [Full Text] http://www.townsendletter.com/April2007/shorts0407.htm.

11. Martin, W. J. (2001). "Stealth Viruses." Explore Issue: Volume 10, Number 4: [Full Text] http://www.explorepub.com/articles/martin_10_4.html
    Bacterial sequences incorporated within stealth-adapted viruses may help explain positive findings in stealth virus infected patients in various tests for known bacteria, including Borrelia burgdoferi (the cause of authentic Lyme disease), mycoplasma (a suggested cause of CFS and Gulf War syndrome); chlamydia (implicated in coronary artery disease and Alzheimer's disease), etc. None of the commonly used assays for these bacteria actually detect cultured organisms, but instead rely upon broadly reactive molecular and/or serological testing that could as easily be explained by the presence of viteria.

12. Lunemann, J. D., H. Gelderblom, et al. (2007). "Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis." Infect Immun 75(1): 243-51. [Full Text] http://iai.asm.org/cgi/reprint/75/1/243  

13. Martin, W. J. (2002). "Chemokines and Stealth Viruses:A Blueprint for Therapy in Infected Humans and Animals " Explore Issue: Volume 11, Number 1: [Full Text] http://www.explorepub.com/articles/martin_11_1.html.

14. Pancewicz, S. A., R. Rutkowski, et al. (2007). "[Immunopathology of Lyme arthritis]." Pol Merkur Lekarski 23(134): 141-4. [PubMed Abstract] 
    Lyme borreliosis (Lyme disease) is the most prevalent tick-borne disease caused by spirochaetes of the Borrelia species complex. Arthritis is one of the common manifestations of B. burgdorferi infection. The pathomechanism of articular changes in Lyme arthritis has not yet been elucidated. Histopathological studies of synovia and immunological changes are similar to rheumatoid arthritis. In the early stage of inflammation B. burgdorferi interact with polynuclear granulocytes and epithelial cells, triggering production of reactive oxygen species, lipid peroxidation products and other inflammatory mediators. The imbalance between anabolic and catabolic processes in inflamed joints results in the progressive destruction of articular cartilage and disintegration of extracellular matrix. Molecular mimicry between OspA (outer surface protein A) and adhesion molecule LFA-1alpha seems to be responsible for chronic arthritis. (Pancewicz,2007).

15. Raveche, E. S., S. E. Schutzer, et al. (2005). "Evidence of Borrelia autoimmunity-induced component of Lyme carditis and arthritis." J Clin Microbiol 43(2): 850-6. [Full Text] http://jcm.asm.org/cgi/content/full/43/2/850?view=long&pmid=15695691 
    We investigated the possibility that manifestations of Lyme disease in certain hosts, such as arthritis and carditis, may be autoimmunity mediated due to molecular mimicry between the bacterium Borrelia burgdorferi and self-components. We first compared amino acid sequences of Streptococcus pyogenes M protein, a known inducer of antibodies that are cross-reactive with myosin, and B. burgdorferi and found significant homologies with OspA protein. We found that S. pyogenes M5-specific antibodies and sera from B. burgdorferi-infected mice reacted with both myosin and B. burgdorferi proteins by Western blots and enzyme-linked immunosorbent assay. To investigate the relationship between self-reactivity and the response to B. burgdorferi, NZB mice, models of autoimmunity, were infected. NZB mice infected with B. burgdorferi developed higher degrees of joint swelling and higher anti-B. burgdorferi immunoglobulin M cross-reactive responses than other strains with identical major histocompatibility complex (DBA/2 and BALB/c). These studies reveal immunological cross-reactivity and suggest that B. burgdorferi may share common epitopes which mimic self-proteins. These implications could be important for certain autoimmunity-susceptible individuals or animals who become infected with B. burgdorferi. (Raveche,2005).

16. Shelton, B. (2007). "Lyme disease diagnoses and therapy will be litmus test for pleomorphism, Enderlein Sanum therapy." (Dec): [Full Text] www.drbruceshelton.com/index2.php?option=com_content&do_pdf=1&id=28
    Lyme is considered to be the hidden epidemic of our time that is a spirochete caused infection transmitted by a bite from a tick and can present as severe arthritic problems and associated skin rashes. The several blood tests that are used to test for it seem to be positive in 90-100% of patients tested as if it cross reacts immunologically with other germs making it hard to know whether the patient being tested has Lyme disease or something else but which can cause fatal problems if not addressed quickly and aggressively.

17. Schneider, P. (2001). "Prof. Enderlein’s Research in Today’s View: Can his research results be confirmed with modern techniques?" SANUM-Post magazine (56/2001) Semmelweis-Institut GmbH Verlag für experimentelle Onkologie GmbH · 27316 Hoya · Germany: [Full Text] http://www.pferdemedizin.com/peter/enderlein_engl.pdf.

18. Waterhouse, J. C. (2007). "Vitamin D, the Vitamin D Receptor and Chronic Disease -- Brain Lesions, Vascular Calcification and Osteoporosis: Two Views of Vitamin D Supplementation and Parathyroid Hormone " CISRA's Synergy Health Newsletter, Issue 11 --Preview, November 19: [Full Text] http://members.aol.com/SynergyHN/shpt.

19. Waterhouse, J. C. (2007). "The Marshall Protocol for Lyme disease and other chronic inflammatory conditions. I." The Townsend Letter for Doctors and Patients April No. 285: [Full Text] http://winmlm.neostrada.pl/mp/townsend/Townsend_Apr07.PartOne.pdf      

20. Waterhouse, J. C. (2007). "The Marshall Protocol for Lyme disease and other chronic inflammatory conditions II." The Townsend Letter for Doctors and Patients May No. 286: [Full Text]
http://winmlm.neostrada.pl/mp/townsend/Townsend_Letter_May2007.Part2.pdf  

21. Weiselfish-Giammatteo (2005) "Infectious Disorders Course" Connecticut School of Integrative Manual Therapy with Dialogues in Contemporary Rehabilitation. http://www.CenterIMT.com

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